Small Fiber Neuropathy & Autoimmune Disorders

 Inflammation in the body from EDS and symptomatic hypermobility often lead to some type of autoimmune disorder, or undifferentiated autoimmune disorder. This means that you have an autoimmune condition, but not enough diagnostic evidence to specify which one. The sensitivity of tests for autoimmune issues is also still a significant problem. A simple ANA panel is typically never enough to catch an autoimmune condition when its in an early enough stage to nurture into remission quickly.

While small fiber neuropathy can have many origins, from diabetes to vitamin deficiencies, autoimmune SFN is the most common autoimmune condition to develop in adults with Ehlers-Danlos Syndromes. In children, interestingly, Sjogren’s is the most frequently occurring autoimmune disorder, but even that is very rare (Dr. Sheetal Vora, Atrium Health Levine Children’s Hospital, North Carolina). Children with a hypermobility spectrum disorder like EDS will most often show symptoms of early mast cell dysfunction, and mast cells are an integral component of the immune system.

Disclaimer: The information contained on this site and the supporting attachments provided by Rachel Lee Patient Advocacy Consulting are for educational purposes only. Although we have performed extensive research regarding medical conditions, treatments, diagnoses, protocols and medical research, the staff of Rachel Lee Patient Advocacy Consulting are not licensed members of the North Carolina Medical Board or any clinical affiliates including but not limited to the NC Board of Physical Therapy Examiners, the NC board of Licensed Professional Counselors, or the NC board of Dietetics/Nutrition. Information provided by members of Rachel Lee Patient Advocacy Consulting should not be considered a substitute for the advice of a licensed medical doctor, counselor, therapist or other licensed clinical practitioner in handling your medical affairs.